A Hair Growth Enhancing Agent
Biol Pharm Bull. 2008 Mar;31(3):449-53.
t-flavanone, a hair regrowth enhancing active component,decreases TGF-beta2)…..
Sasajima M, et al
t-flavone is a synthetic compound with hair regrowth enhancing activity that is effective against male pattern alopecia.t-Flavanone was designed as a derivative of astilbin, the active hair growth enhancing component of Hypericum perforatum extracts. This study was designed to elucidate the mechanism of hair regrowth enhancement by t-flavanone. We investigated the effects of t-flavanone on transforming growth factor beta (TGF-beta), a known catagen-inducing factor induced in hair papilla cells by male hormone. When t-flavanone was added to cocultures of human hair papilla cells and human keratinocytes, there was no change in the total level of TGF-beta2. However, levels of active TGF-beta2 were reduced, suggesting the involvement oft-flavanone in the activation pathway of TGF-beta2. ….. t-Flavanone is a hair regrowth enhancing component that has a novel mechanism of action which suppresses TGF-beta2 activation, and thereby is expected to treat other types of alopecia in addition to male pattern hair loss.
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